Studie(s) en diploma's

2010-2014 PhD in Biomedical Engineering - Joint degree KU Leuven – U. Liège
Thesis: “Multiscale modeling of angiogenesis during normal and impaired bone regeneration”
Promotors: Prof. dr. ir. H. Van Oosterwyck and Prof. dr. ir. Liesbet Geris

2008-2010 Master of Science in Biomedical Engineering, KU Leuven - summa cum laude (88%)
2008-2009 École Polytechnique Fédérale de Lausanne, Switzerland - Erasmus (6 months)
2005-2008 Bachelor of Science in Engineering, KU Leuven - magna cum laude (83%)

Huidige functieomschrijving

assistant professor

Ervaring

> 10 jaar in de wiskundige modellering van biologische processen
> 4 jaar assistant professor

Relevante Publicaties

1. Karagöz, Z., Geuens, T., LaPointe, V.L.S., van Griensven, M., Carlier, A. (2021) Win, lose or tie: mathematical modeling of ligand competition at the cell-extracellular matrix interface. Frontiers in Bioengineering and Biotechnology, section Tissue Engineering and Regenerative Medicine, https://doi.org/10.3389/fbioe.2021.657244

2. King, J., Eroumé, K., Truckenmüller, R., Giselbrecht S., Cowan, A.E., Loew, L., Carlier, A. (2021) 10 steps to investigate a cellular system with mathematical modeling. PLoS Computational Biology, https://doi.org/10.1371/journal.pcbi.1008921

3. Yang, L., Pijuan-Galito, S., Suk Rho, H., Vasilevich, A., Dede Eren, A., Ge, L., Habibovic, P., Alexander, M., de Boer, J., Carlier, A., van Rijn, P., Zhou, Q. (2021) High-throughput methods in the discovery and study of biomaterials and materiobiology. Chemical Reviews, https://doi.org/10.1021/acs.chemrev.0c00752

4. Eroumé, K., Vasilevich, A., Vermeulen, S., de Boer, J., Carlier, A. (2021) On the influence of cell shape on dynamic reaction-diffusion polarization patterns. PLoS One, doi:10.1371/journal.pone.0248293

5. Karagöz, Z., Rijns, L., Dankers, P., van Griensven, M., Carlier, A. (2021) Towards understanding the messengers of extracellular space: computational models of outside-in integrin reaction networks. Computational and Structural Biotechnology Journal, 19:303-314, https://doi.org/10.1016/j.csbj.2020.12.025

6. Vasilevich, A., Carlier, A., Winkler, D., Singh, S., de Boer, J. (2020) Evolutionary design of optimal surface topographies for biomaterials. Scientific Reports, 10(1):22160, https://doi.org/10.1038/s41598-020-78777-2.

7. Vasilevich, A., Vermeulen, S., Kamphuis M., Roumans, N., Eroumé, S., Hebels, D., van de Peppel, J., Reihs, R., Beijer, N., Carlier, A., Carpenter, A., Singh, S., de Boer, J. (2020) On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells. Scientific Reports, 10(1):18988, doi: 10.1038/s41598-020-76019-z.

8. Vermeulen, M., Roumans, N., Honig, F., Carlier, A., Hebels, D., Dede Eren, A., ten Dijke, P., Vasilevich, A., de Boer, J. (2020) Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells. Biomaterials, https://doi.org/10.1016/j.biomaterials.2020.120331

9. Vassey, M., Figueredo, G.P., Scurr, P., Vasilevich, A., Vermeulen, S., Carlier, A., Luckett, J., Beijer, N., Williams, P., Winkler, D., de Boer, J., Ghaemmaghami, A.M., Alexander, M.R. (2020) Immune modulation by design: using topography to control human monocyte attachment and macrophage differentiation. Advanced Science (WoS JCR 2018, IF 2018 = 15.804, position 14/293 in ‘Materials science, multidisciplinarity, Q1)

10. van Gastel, N., Stegen, S., Eelen, G., Schoors, S., Carlier, A., Daniëls, V., Baryawno, N., Przybylzki, D., Depypere, M., Stiers, P-J., Lambrechts, D., Van Looveren, R., Torrekens, S., Sharda, A., Agostinis, P., Lambrechts, D., Maes, F., Swinnen, J., Geris, L., Van Oosterwyck, H., Thienpont, B., Carmeliet P., Scadden, D., Carmeliet, G. (2020) Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature, https://doi.org/10.1038/s41586-020-2050-1 (WoS JCR 2018, IF 2018 = 43.070, position 1/69 in ‘Multidisciplinary sciences’, Q1)

11. Grivas, K., Vavva, M., Demosthenes, P., Carlier, A., Geris, L., Van Oosterwyck, H., Fotiadis, D. (2019) Effect of ultrasound on bone fracture healing: a computational mechanobioregulatory model. Journal of the Acoustical Society of America, 145, 1048, https://doi.org/10.1121/1.5089221

12. Vavva, M., Grivas, K., Carlier, A., Demosthenes, P., Geris, L., Van Oosterwyck, H., Fotiadis, D. (2018) Effect of ultrasound on bone fracture healing: a computational bioregulatory model. Computers in Biology and Medicine, https://doi.org/10.1016/j.compbiomed.2018.06.024

13. Geris, L., Lambrechts, T., Carlier, A., Papantoniou, I. (2018) The future is digital: in silico tissue engineering. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2018.04.001

14. Kumari, S., Vermeulen, S., van der Veer, B., Carlier, A., de Boer, J., Subramanyam, D. (2018) Shaping cell fate: influence of topographical substratum properties on embryonic stem cells. Tissue Engineering part B, doi:10.1089/ten.TEB.2017.0468

15. Carlier, A., Vasilevich, A., Marechal, M., de Boer, J., Geris, L. (2018) In silico clinical trials for pediatric orphan diseases. Scientific Reports, 6;8(1):2465, doi:10.1038/s41598-018-20737-y

16. Hebels, D.G.A.J, Carlier, A., Coonen, M.L.J., Theunissen, D.H., de Boer, J. (2017) cBiT: a transcriptomics database for innovative biomaterial engineering. Biomaterials, https://doi.org/10.1016/j.biomaterials.2017.10.008

17. Vasilevich, A., Carlier, A., de Boer, J., Singh, S. (2017) How not to drown in data: a guide for biomaterial engineers. Trends in Biotechnology, https://doi.org/10.1016/j.tibtech.2017.05.007

18. Carlier, A., Alsber, E. (2016) Special collection: Harnessing topographical cues for Tissue Engineering. Tissue Engineering part A, 22:15, doi:10.1089/ten.tea.2016.0188

19. Carlier, A., Akdeniz Skvortsov, G., Hafezi, F., Ferraris, E., Patterson, J., Koc, B., Van Oosterwyck, H. (2016) Computational model-informed design and bioprinting of cell-patterned constructs for bone tissue engineering. Biofabrication, 8:2, http://dx.doi.org/10.1088/1758-5090/8/2/025009

20. Carlier, A., Brems, H., Ashbourn, J.M.A., Nica, I., Legius, E., Geris, L. (2015). Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study. Sci Rep, 6, 20010, doi:10.1038/srep20010

21. Carlier, A., Lammens, J., Van Oosterwyck, H., Geris, L. (2015). Computational modeling of bone fracture non-unions: four clinically relevant case studies. In Silico Cell Tissue Sci, 2:1, doi: 10.1186/s40482-015-0004-x

22. Carlier, A., Geris, L., Lammens, J., Van Oosterwyck, H. (2015). Bringing computational models of bone regeneration to the clinic. WIREs Syst Biol Med, doi:10.1002/wsbm.1299

23. Carlier, A., van Gastel, N., Geris, L., Carmeliet, G., Van Oosterwyck, H. (2014). Size does matter: an integrative in vivo-in silico approach for the treatment of critical size bone defects. PLoS Comput Biol, 10(11), e1003888, https://doi.org/10.1371/journal.pcbi.1003888

24. Carlier, A., Geris, L., van Gastel, N., Carmeliet, G., Van Oosterwyck, H. (2014). Oxygen as a critical determinant of bone fracture healing – a multiscale model. J Theor Biol, 365, 247-264, doi: 10.1016/j.jtbi.2014.10.012

25. Carlier, A., Geris, L., Bentley, K., Carmeliet, G., Carmeliet, P., Van Oosterwyck, H. (2012). MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells. PLoS Comput Biol, 8(10), e1002724, https://doi.org/10.1371/journal.pcbi.1002724

26. Chai, Y.C., Carlier, A., Bolander, J., Roberts, S.J., Geris, L., Schrooten, J., Van Oosterwyck, H., Luyten, F.P. (2012). Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies. Acta Biomaterialia, 8(12), 3876-3887, https://doi.org/10.1016/j.actbio.2012.07.002

27. Carlier, A., Chai, Y., Moesen, M., Theys, T., Schrooten, J., Van Oosterwyck, H., Geris, L. (2011). Designing optimal calcium phosphate scaffold-cell combinations using an integrative model based approach. Acta Biomaterialia, 7, 3573-3585, https://doi.org/10.1016/j.actbio.2011.06.021

Mijn media ervaring

Mondeling
BNR – Wetenschap Vandaag – 10 june 2021 “Wie wordt het wetenschapstalent van 2021?” - https://www.bnr.nl/podcast/wetenschap-vandaag/10444122/wie-wordt-het-we…

NPO1 – Focus Wetenschap – 10 june 2021 “Wie is dit jaar het grootste wetenschappelijke talent van Nederland en Vlaanderen?” – “Een virtueel proefpersoon die helpt bij het begrijpen van botbreuken” - https://plinkhq.com/i/791101885/e/1000524910599

Elsevier FlashSciTalk – 29 march 2021 “Impact of COVID on gender equality in academia” - https://www.youtube.com/watch?v=JNIKegBj564

Geschreven:
The New Scientist, 5 june 2021 “Een computermodel kan virtueel extra proefpersonen bijmaken” -
https://www.newscientist.nl/nieuws/een-computermodel-kan-virtueel-extra…

De Limburger, 5 may 2021 “Knappe koppen UM brengen wetenschap naar praktijk” - https://www.limburger.nl/cnt/dmf20210504_94712813

1Limburg, 29 april 2021 “Onderzoekers UM in de race voor titel wetenschapstalent 2021”- https://www.1limburg.nl/onderzoekers-um-de-race-voor-titel-wetenschapst…

De Limburger, 28 april 2021 “Onderzoekers UM in de race voor titel wetenschapstalent van het jaar” - https://www.limburger.nl/cnt/dmf20210428_93310918

ScienceGuide, 20 april 2021 “De genderkloof in wetenschappelijke citaties maakt vrouwen onzichtbaar” - https://www.scienceguide.nl/2021/04/de-genderkloof-in-wetenschappelijke…